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KMID : 0363220080460050648
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Korean Journal of Dermatology
2008 Volume.46 No. 5 p.648 ~ p.651
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A Case of Leukocytoclastic Vasculitis after Use of Sorafenib (Nexavar(R)
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Kim Hak-Ju
Kim Ji-Hye
Kim June-Bum
Kim Hye-Kyoung
Ko Yoo-Soo
Joh Ok-Ja
Lee Jae-Seung
Song Kye-Yong
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Abstract
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Sorafenib (Nexavarⓡ) is an oral multikinase inhibitor that was recently approved for use in metastatic renal cancer.
It is currently undergoing investigation for the treatment of locally advanced renal cancer and in other tumor types.
It has a broad spectrum of activity in treating multiple tyrosine kinases, including angiogenic factors VEGFR and PDGFR. Common cutaneous toxicities experienced with sorafenib include facial and scalp erythema, hand-foot syndrome, splinter hemorrhages, and alopecia. We report a case of a 57 year-old man diagnosed as renal cell carcinoma with distant metastaisis, who developed a leukocytoclastic vasculitis on the extremities after use of sorafenib. (Korean J Dermatol 2008;46(5):648∼651)
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KEYWORD
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Leukocytoclastic vasculitis, Nexavar(R), Sorafenib
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